HARMONI fosters European innovation

As stakeholders from the European process industry continue their search for measures to facilitate the transfer of innovation to the market, the Horizon 2020 funded SPIRE project HARMONI (Harmonised assessment of regulatory bottlenecks and standardisation needs for the process industry) has acted as a catalyst, bringing together over 150 experts to foster innovation activities.

On 16 and 17 January, the 2019 HARMONI Summit took place with the objective to encourage dialogue on an effective framework to facilitate and foster innovation. More than 150 experts from all sectors of the process industry, the European Commission and European standardisation bodies engaged in the exchange of ideas.

Summit solutions

The summit addressed solutions for non-technological challenges that hinder innovation and the transfer of solutions, such as regulation, standardisation needs and the lack of innovative business models. Based on the themes within the HARMONI project, the summit selected priority discussion areas that included innovation transfer and the harmonisation of EU regulation and EU standardisation.

Six sessions took place during the two-day workshop, dealing with context specific priority areas, such as the circular economy, CO2 valorisation and waste management. Each session included experts, and opportunity for Q&A’s, as well as working groups and discussion panels. This allowed for a hands-on evaluation of possible solutions for industry needs while, in parallel, giving a voice for representatives from the European Commission in an open and transparent dialogue.

HARMONI, in the words of the DG Research and Innovation, “can play a very interesting role in the future of the Horizon Europe Programme”, especially due to its good practise of integrating regulation and standardisation.

What’s next?

The HARMONI project continues until October 2019. The results of the project mainly address industry, regulatory and standardisation bodies. Identified priorities and results from the working groups will serve to provide recommendations to the responsible authorities.

The HARMONI team welcomes your input and looks forward to engaging with you in order to move towards a sustainable and competitive European process industry. Why not subscribe to the HARMONI newsletter to keep up to date with upcoming events and results?

More information on Harmoni

HARMONI aims to bring together all the relevant stakeholders in the process industry to jointly identify, analyse and propose solutions to the regulatory bottlenecks and standardisation needs that hamper their innovation processes and the market uptake of their results.

To do this, the project is developing and applying a methodology that ensures effective collaboration between the eight sectors involved in the SPIRE contractual Public Private Partnership to elaborate the solutions to the common challenges they face due to non-technological barriers including regulatory issues and lack of appropriate European Standards relevant to improving resource efficiency. In addition, HARMONI is analysing, comparing and proposing recommendations to trigger the transferability of technical solutions among and beyond the SPIRE sectors.

The project activities should enable an optimised EU regulatory and standardisation framework that facilitates and supports innovation in the process industry; improved participation of the SPIRE community in EU regulatory and procedures; earlier and more active involvement of the SPIRE community in the EU standardisation process; and an overall better environment that maximises transferability rates for technologies across SPIRE sectors.

For more information, please take a look at the HARMONI website.

2015 LRI Innovative Science Award Winner Announced

French researcher Dr. Alice Limonciel was awarded the €100,000 LRI Innovative Science award, one of Europe’s largest research grants for early career scientists, at an award ceremony at Cefic’s 17th Annual Long-Range Initiative (LRI) Workshop in Brussels on November 18, 2015.

Dr.  Limonciel’s winning research proposal is entitled "Establishment of thresholds of activation of stress
responses pathways and ligand-activated receptors for chemical classification” and will investigate cellular responses to the acceleration of chronic kidney disease progression due to chemical exposure. The project aims to identify the genes involved in cellular stress response pathways, quantify these responses in parallel with markers of cellular dysfunction and deliver a new generation of quantitative tools based on gene expression to evaluate the hazard linked to chemical exposure for use in risk assessment strategies.

Dr. Pierre Barthélemy, Cefic Executive Director of Research and Innovation commented: “It’s always a pleasure to see the enthusiasm of early career scientists and their desire to make our world safer. The LRI Innovative Science is a great opportunity for them to develop their breakthrough ideas with complete freedom, find new approaches to tackle risk assessment and help reduce uncertainty as it relates to chemicals safety”.

Dr. Limonciel (pictured above, right, receiving the award from Yves Verschueren Managing Director of Essenscia)  studied pharmacology and toxicology at the engineering school Polytech’ Nice-Sophia in France. She completed her doctoral studies in the department of Physiology and Medical Physics at the Medical University of Innsbruck, Austria in 2013.  Dr. Limonciel is currently working at Innsbruck as a Postdoctoral researcher on molecular mechanisms of nephrotoxicity notably using the integration of multiple omic datasets such as transcriptomics, proteomics, metabolomics and epigenomics.

A video from the LRI Award ceremony 2015 is embedded below. 



The award ceremony and dinner were the highlights of the first day of the 2015 Annual CEFIC-LRI Workshop. The second day of the workshop will focus on non–animal-based safety assessment and will showcase the outcome and impact of several LRI projects completed in 2014-2015 from the fields of environmental risk assessment, bioconcentration, chemo-informatics, exposure modelling, skin sensitization and acceptance of innovation.

About the Award
The LRI Innovative Science Award worth €100 000 was first introduced in 2004 as a funding opportunity for young scientists based in Europe. Its aim is to stimulate innovative research, to foster ‘out-of-the-box’ thinking and to introduce new approaches that will advance the environmental assessment of hazardous substances. More than a decade later, it is still the biggest award of its kind in Europe and has helped numerous scientists realise their ambitions and become part of the LRI scientific network.

The Long-range Research Initiative (LRI) is part of Cefic's voluntary initiatives to improve the Regulatory Framework of the chemical industry in Europe. Its mission is to identify and fill gaps in our understanding of the hazards posed by chemicals and to improve the methods available for assessing the associated risks.

For more information on the LRI activities and the award, please contact Programme Manager Bruno Hubesch.

LRI Workshop looks at progress in Non-animal-based safety assessment

Don’t forget the Long-Range Research Initiative Programme (LRI) of the European Chemical Industry Council (Cefic) is holding its 17th annual workshop on 18 and 19 November 2015 in Brussels. This year, the Annual CEFIC-LRI Workshop will focus on non–animal-based safety assessment and will showcase the outcome and impact of several LRI projects completed in 2014-2015 from the fields of environmental risk assessment, bioconcentration, chemo-informatics, exposure modelling, skin sensitization and acceptance of innovation.

Registration is now open and free!
The Cefic-LRI workshop is a must-attend event for the scientific community and an excellent networking opportunity for policymakers. This year’s venue is Le Plaza Hotel Brussels.

On the evening of the first day the LRI programme will present the winner of the LRI Innovative Science Award for 2015 and also catch up with the progress of winner of the 2014 LRI Award winner Dr Alexandra Antunes of the Centro de Química Estrutural, Complexo Interdisciplinar Instituto Superior Técnico in Portugal and her work on Covalent Modification of Histones by Carcinogens: a novel proteomic approach toward the assessment of chemically-induced cancers.

AMBIT tool
The second day will feature plenary sessions on the impact of LRI projects that cover subjects including an integrated modelling tool for ecological risk assessment, a mechanistic bioconcentration model for ionogenic organic compounds in fish, passive sampling formats, exposure modelling platforms and much more.

One of the presentations will feature the project to revise and update the AMBIT tool as a predictive toxicity model based on read-across and category formation. The tool can be used for both research and regulatory purposes and will be released in early 2016 and will be fully loaded and formatted with the non-confidential part of the REACH database. LRI will soon organize hands-on training to familiarize research experts with this new web-based application. Keep an eye on the LRI website for more announcements on this.

Panel discussion
And in the afternoon of Day 2, Prof Ian Kimber of the University of Manchester with moderate a dedicated panel discussion on non-animal-based safety assessment to consider the questions: “Non-animal based safety assessment: within reach or over-sold? Do we need to set back expectations?”

The panel will focus on current and future developments in non-animal toxicity testing methods and address the key issues and challenges to developing non-animal methods in toxicology. It will also examine visionary versus unrealistic regulatory expectations e.g. in view of REACH 2018.

The panel will consist of:

• Dr Karel de Raat, ECHA
• Dr Karen Niven, Shell
• Dr Alan Poole, ECETOC
• Dr Rick Becker, American Chemistry Council
• Dr Raffaella Corvi, JRC/EURL-ECVAM
• Prof Jim Bridges, Univ. Surrey
• Dr Kirsty Reid, Eurogroup for Animals

More information
For more details of the 17th Annual CEFIC-LRI workshop visit the dedicated webpage and download the final programme.

To register for the event, please click here.

You can follow the event on Twitter via the hashtag #lri2015

For more information on the workshop, please contact Dr. Bruno Hubesch, LRI Programme Manager or the LRI Secretariat.

More about LRI
The Long-range Research Initiative (LRI) programme is a major voluntary initiative of the European chemical industry to support the long-term sustainability of its sector and European society. Through the programme we hope to identify the hazards posed by chemicals and improve the methods available for assessing the associated risks.

The LRI sponsors high-quality research of a standard publishable in a reputable peer-reviewed journal, and seeks to provide sound scientific advice on which industry and regulatory bodies can draw-on to respond quickly and accurately to the public's concerns.

LRI research supports the 3R's principle. Read more here: http://cefic-lri.org/lri-research-programme/research-areas/intelligent-testing/ and http://cefic-lri.org/news/cefic-lri-in-joint-cross-sector-workshop-on-alternatives-for-skin-sensitization-testing-and-assessment/.

REACH and Innovation

As part of its extensive review of the REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) Regulations the European Union has commissioned a new survey to assess the impact of the regulations on launched the innovativeness of the chemical industry in Europe.

The survey, which will be open for input until 7 October 2011, is being conducted by the Centre for Strategy and Evaluation Services (CSES) on behalf of the European Commission DG Enterprise and Industry.

This innovation survey forms part of a wider exercise to evaluate the effects of REACH and to inform future amendments to the legislation.

Chemical stakeholders
The online survey of businesses across the European Union will receive feedback on key issues related to the implementation of the REACH Regulation. The survey targets manufacturers and importers of chemical substances but also downstream users, distributors of chemicals and other firms involved in the different stages of the chemicals supply chain that may be affected by the REACH Regulation and is available in all European languages.

Views are solicited on innovation from product conception through testing and piloting to production. Within the interpretation of the term “innovation” is included product, process, marketing and organisational innovation.

For more information on the purpose of the study, please contact Jan Smits, REACH evaluation project leader at CSES. The survey can be found here.

International regulation key to nanotech growth

SusChem board member Gernot Klotz of Cefic R&I highlighted the need for a coherent approach to international regulation for nanotechnologies at the EU-US High Level Regulatory Cooperation Forum in Brussels today (8 June).

The event, co-organised by BusinessEurope and the US Chamber of Commerce, also involved the EU Commission and the Transatlantic Business Dialogue - the main business voice with the U.S .Government and the European Union on the transatlantic economic relationship.

Dr. Klotz made the opening statement and outlined the business perspective in a panel discussion on nanotechnologies to which US and EU regulators then responded. He is the coordinator for High Level Group on Key Enabling Technologies working group on nanotechnology.