Cefic - LRI 2017 programme call closes 31 August!

The Long-range Research Initiative (LRI) programme of the European Chemical Industry Council (Cefic) is now accepting grant applications, but you will need to be quick as the deadline for applications is 31 August 2017.

The Long-range Research Initiative (LRI) programme is a major voluntary initiative of the European chemical industry to support the long-term sustainability of its sector and European society. The programme funds work to identify the hazards posed by chemicals and improve the methods available for assessing the associated risks.

The LRI sponsors high-quality research of a standard publishable in a reputable peer-reviewed journal, and seeks to provide sound scientific advice on which industry and regulatory bodies can draw-on to respond quickly and accurately to the public’s concerns.

2017 call
The 2017 call covers research in the following areas:

• Bioaccumulation potential determination (ECO41)
• Fate-ecotoxicity testing and risk assessment (ECO42)
• Sediment toxicity testing refinement (ECO43)
• Toxicokinetics mammalian modelling (ECO44)
• Implementing an ecosystem services-based approach to chemical risk assessment: A proof of concept study (ECO45)
• Improvement of the environmental hazard and risk assessment of cationic polymers (ECO46)
• Assessment of inhalation and dermal exposure in industrial/professional use (B20)Interpretation of ‘omics (molecular-level interactions data):
• Development of omics data analysis (C4)
• Understanding normal adaptation vs pathology and gene expression time dependence (C5)
• Biological omics read-across (C6)

Further information on project specifications, budget details and application forms can be found on the Cefic-LRI website at:

Only proposals that fit the project specifications and are submitted via the official LRI application form will be considered for funding. For further details, please contact Dr. Bruno Hubesch, LRI Programme Consultant, or the LRI Secretariat via email.

The deadline for receipt of completed applications is 31 August 2017.

A mini-guide to the Cefic-LRI funding and application process can be downloaded here and results from a selection of completed Cefic-LRI projects can be found here.

About Cefic-LRI
The Cefic-LRI programme is all about a responsible approach to assessing the long-term impacts of chemicals.

Public awareness of the potential impact of human activity and man-made substances on the environment and on health is something the chemical industry has long taken seriously. As early as 1996, the need to address societal concerns and help public understanding of the long-term impacts led to the establishment of the Long-range Research Initiative (LRI) programme in the US. Cefic-LRI manages the LRI programme in Europe.

The LRI’s aim is to respond to public and stakeholder concerns through rigorous scientific investigation. In the last 17 years it has become a unique source of knowledge and tools, providing a validated infrastructure of scientific advice available to both the industry and regulatory bodies. In this way, the LRI helps to provide timely and accurate information in response to the public’s questions and concerns.

To help address some of European public health strategy priorities, LRI conducts peer-reviewed transparent research to:
-Improve risk assessment of chemicals and monitor the effects of chemicals on health;
-Understand the environmental factors in human health;
-Establish endocrine disruption references;
-Coordinate research, data and activities at a European level.

LRI also addresses many of the environmental objectives of the EU, including:
-Linking environmental factors to health effects;
-Understanding and reducing chemical risks to environment;
-Improving animal testing in risk assessment.

Additional Cefic-LRI Grants for 2013 Announced

The Long-range Research Initiative (LRI) is a major voluntary initiative of the European chemical industry to support its competitiveness and innovation potential. The LRI programme aims to identify and fill gaps in the understanding of the hazards posed by chemical substances and to improve the methods available for assessing the associated risks. Requests for proposals in a range of research areas were published in June and now two further topics have been published for research commencing in 2014.

LRI sponsors high-quality research, published in peer-reviewed journals, and seeks to provide sound scientific advice on which industry and regulatory bodies can draw to respond more quickly and accurately to society’s concerns.

In addition to the LRI programme for 2013 announced in June, the European Chemical Industry Council (Cefic) is now accepting further grant applications to carry out research in the following areas:

• LRI-AIMT4: Use of non-animal data to supplement and strengthen read-across
• LRI-C3: Epigenetics - Normality in Toxicologically Relevant Species

Further details of each research area can be found by following the links on each topic.

Applications
The submission deadline for these two extra research areas is 10 January 2014. Project specifications, budget details and application forms can be found on the Cefic LRI website. Only proposals that fit the project specifications and are submitted via the official LRI application form will be considered.

The scientific evaluation and selection of applications for funding are managed by a scientific committee provided by ECETOC. In particular, within LRI, ECETOC has the responsibility of maintaining three “core teams”: health effects, human exposure & risk assessment and environment.

LRI events
Dr. Bruno Hubesch, Cefic-LRI Manager  will be chairing the session on low dose toxicity at the 34th Annual European Meeting of the Toxicology Forum (ToxForum) that takes place on 22 to 24 October in Brussels.

ToxForum aims to be recognised as the leading international toxicological organisation promoting and encouraging dialogue amongst all stakeholders on public health issues.

And don’t forget the 15th Cefic-LRI Annual Workshop that takes place on 20 to 21 November 2013, also in Brussels. The 2013 workshop will discuss how a science-informed approach to decision-making can contribute to relevant policy initiatives. The event will showcase the results and outcomes of several LRI projects completed in 2012-2013. The key areas of discussion will be thresholds of concern, bio-monitoring, domestic exposure, endocrine disrupters, nanomaterials, toxicogenomics and sediment testing.

You can find more information on the workshop here or go straight to registration here.

More information on LRi
For further information, please contact Dr. Bruno Hubesch, Cefic-LRI Manager, or the LRI Secretariat or visit the Cefic-LRI website.

Dialogue on Nano

The English language publication of the findings from the Dialogforum on Nano organised by BASF was celebrated at a public event yesterday (24 June) in Brussels. This important communication examined how we can effectively communicate in a transparent way on nanomaterials from manufacturers to consumers. Its findings reflect other recent industry communications in the area of nanotech.

What do consumers want to know about nanotech-enabled products? And how should manufacturers and retailers communicate? Does a definition of nano help, what is the role of labelling and would a mandatory register help?

These questions and more were on the agenda of the Dialogforum Nano organised by BASF. This initiative brought together representatives of German environmental and consumer organisations, churches, industry, retailers, research organisations and trade unions to develop shared recommendations for increasing transparency and information on nano-materials along the value chain from manufacturer to the consumer.

To achieve this involved a process that included analysis of  consumer enquiries to companies and consumer organisations, expert hearings the availability of relevant scientific information and safety testing of nanomaterials.

You can access the final report of the Dialogforum here and see a summary of the 24 June event including contributions from panelists and the audience can be accessed here.

Seven questions
The essence of the recommendations of the Dialogforum is summarised in seven questions for the supply chain:

1. Information on the nanomaterial used: How can the material be characterised?
2. Does the EU definition recommendation for nanomaterials apply to the material in question?
3. A/ How can the effect and the new functionality generated through the nanomaterial be explained? B/ How can the effect and the new functionality be explained if the material in question is not a nanomaterial?
4. How can the added value of the nanomaterial be described compared to other products?
5. How is the risk assessment of the used materials carried out? With what results?
6. How is the material / product in question to be recycled / disposed of / handled at the end-of-pipe?
7. Where can further information be found?

During the discussion on 24 June a key element for the success of the Dialogforum was the establishment of a common language / vocabulary to remove ambiguity and allow common understanding between the various stakeholder. It is hoped to develop the dialogue at a pan-European level.

Mindset change
Gernot Klotz, Executive Director for Research and Innovation at Cefic and SusChem board member addressed the recent EuroNanoForum in Dublin on June 18 with a similar message.

He called for a mindset change in Europe. In the face of the many pressing societal challenges—such as renewable energy and an ageing population —that we face it is essential that we develop key enabling technologies (KETs) such as nanotechnology.

However successful development of KETs requires that both public and political perceptions of the technologies are able to comprehend the relative and differentiated balance of risk and benefit for their wide range of applications.

He argued that “to achieve global leadership in nano and maximise its benefits to society, the benefits and risks research in new technology areas should be tackled together.  The innovation and safety community must work together to ensure that we master these technologies and push forward applications where the use of nano is regarded as safe.”

That means an integrated strategy on KETs is needed that will simultaneously:

• Link technologies to their specific uses for solutions for priority European challenges
• Open a structured dialogue between the innovation and safety stakeholder communities
• Promote more research that integrates risks and benefits within its design to provide us robust data on the benefits from innovation that society wants and the related risks society is willing to take to get the benefits
• Explore existing regulations and voluntary approaches for responsible risk management of KETs
• Initiate broad and structured public dialogue about benefits and risks of KETs in specific application areas

“Innovation is about change. And change requires a mindset change in order for us to accept and adapt to change. The proposed approaches must be part of the discussion on societal challenges. We cannot achieve the EU 20-20-20 objectives and enjoy a better life quality if we do not invest in technology,” he concluded.

You can read the full text of Gernot Klotz’s speech here.

Safe and innovative
These themes were also reflected in a joint document published by a range of European industry associations, including the chemical industry, on 14 June. The document, Europe needs safe and innovative nanotechnologies, demonstrates these sectors backing for the European Commission's Second Regulatory Review on Nanomaterials and ‘its conclusion that the current European regulatory framework adequately covers nanomaterials, is science-based and proportionate’.

The paper also states that ‘[…] the REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) Regulation provides the [most] appropriate framework to address nanomaterials […]’ and that openness and transparency are vital for the growth of the nanotechnology industries.

Cefic-LRI Grants 2013 open

The Long-range Research Initiative (LRI) is a major voluntary initiative of the European chemical industry to support its competitiveness and innovation potential. The LRI programme aims to identify and fill gaps in the understanding of the hazards posed by chemical substances and to improve the methods available for assessing any associated risks. The topics in which proposals for research during 2013 are requested have just been announced.

LRI sponsors high-quality research, published in peer-reviewed journals, and seeks to provide sound scientific advice on which industry and regulatory bodies can draw to respond more quickly and accurately to society’s concerns.

In the context of its LRI programme for 2013, the European Chemical Industry Council (Cefic) is accepting grant applications to carry out research in the following areas:

• LRI-B14: Skin sensitisation - chemical applicability domain of the Local Lymph Node Assay (LLNA)
• LRI-B15: Efficiency of Risk Management Measures (RMM)
• LRI-ECO23: Combining passive sampling and toxicity profiling to assess mixture toxicity of surface waters
• LRI-ECO24: Prediction of Non-Extractable Residues (NER) using structural information 
• LRI-ECO25: Development of soup tests for the risk assessment of NER in soil
• LRI-EMSG58: Quality assessment of the epidemiological evidence of adverse effects to humans of endocrine active substances in the environment
• LRI-N4: Grouping nanomaterials and establishing criteria for Safe by Design
• LRI-S3: Benefits and risk evidence streams for decision makers

Further details of each research area can be found by following the links on each topic.

More information
The deadline for applications is 1 September 2013. Project specifications, budget details and application forms can be found on the Cefic LRI website. Only proposals that fit the project specifications and are submitted via the official LRI application form will be considered.

The scientific evaluation and selection of applications for funding are managed by a scientific committee provided by ECETOC. In particular, within LRI, ECETOC has the responsibility of maintaining three “core teams”: health effects, human exposure & risk assessment and environment.

For further information, please read the complete LRI Requests for Proposals on the Cefic LRI website, or contact Dr. Bruno Hubesch, Cefic-LRI Manager, or the LRI Secretariat.