Cefic’s Long-Range Research Initiative (LRI) is organising a training workshop on the AMBIT tool on 21 January at Cefic’s Brussels offices. AMBIT tool is a predictive toxicity model based on read-across and categorisation. The tool is a web-based application freely available to all and could prove very useful for companies for both R&D and regulatory purposes – in particular for REACH.
The AMBIT tool is described on the LRI website and in more detail on its own website and in this presentation from the LRI 2015 programme workshop.
The workshop is entitled ‘Linking LRI AMBIT Chemo informatics system with the IUCLID Substance database to support Read across of Substance endpoint data and Category formation.’
AMBIT is an essential component of the LRI toolbox of methods and instruments, while IUCLID (International Uniform Chemical Information Database) is a key tool for the chemical community to fulfil data submission obligations under REACH. The linking of the two systems was undertaken in LRI project EEM9.3.
The inclusion of high quality substance data will enhance the predictive power of the AMBIT in-silico tool. The new version of AMBIT also implements workflows for assessments and should minimise overall animal testing needs and resource costs.
Another important new feature is the automatic assignment of chemical structures from the AMBIT structure pool to all the constituents, impurities and additives defined in an IUCLID substance. A search for a defined structure yields relevant substances and endpoint data that could be filtered as required by the user.
In addition AMBIT has several output options including the generation of an assessment report as a Word document that itemises justification/ validation of the approach taken.
AMBIT is an open source application with many functions that can be further developed or customised. The EEM9.3 project ended this month (December 2015) and the new version of AMBIT will become a free, open, publicly available tool.
The AMBIT workshop on 21 January will allow users to gain “hands on” experience of the new system.
There is no charge for attendance at the AMBIT workshop but places are restricted to a maximum of 50 participants – so reserve you seat now! You can view the programme of the workshop here.
To register, please send an email to Andreea Udrea withh cc to LRI Programme Manager Bruno Hubesch. Places will be allocated on a ‘first come first served basis’.
For more information on LRI activities, please contact Dr. Bruno Hubesch, LRI Programme Manager or the LRI Secretariat.