LRI Innovative Science Award 2016 to be revealed at Red Carpet Gala Dinner

Join us at a Red Carpet Gala Dinner organised by Cefic-LRI on 16 November 2016 to find out the winner of the 2016 LRI Innovative Science Award. The 2016 awardee will be officially revealed at the glamorous Cefic-LRI Annual Workshop dinner during the first day of the 18th Annual Cefic-LRI Workshop. The Cefic-LRI Red Carpet Gala Dinner will start with a networking poster session at 17:30 followed by the Gala Dinner at 19:30 at Le Plaza Hotel in Brussels.

The LRI Innovative Science Award is an initiative of the European Chemical Industry Council (Cefic), in conjunction with the Society of Environmental Toxicology and Chemistry (SETAC), the Association of European Toxicologists and European Societies of Toxicology (EUROTOX), the International Society of Exposure Sciences (ISES) and Chemical Week. It offers a €100 000 award to support promising new research in the field of novel approaches to the characterisation of molecular initiating events (MIEs), or other key events, in pathways of human and environmental toxicity.

The 2016 award winner will be presented by Dr Nicolas Cudre-Mauroux, Group Head of Research and Innovation at Solvay.

Out of the box
The objective of the LRI Award is to stimulate innovative research, ‘out-of-the-box’ thinking and new approaches, which will advance the development and application of new and existing data in the assessment of chemical safety. The initiative seeks to foster inventive research, focused either on human health or environmental safety that is pioneering new approaches to identifying and characterising MIEs and other key events/biomarkers relevant for important new Adverse Outcome Pathways (AOPs).

Places are filling quickly so if you would like to be part of this special evening on 16 November, please register for the Red Carpet Gala Dinner now here or by 4 November at the latest.

Please note that separate registrations are required for both the Gala Dinner and the Annual Workshop.

If you haven't registered yet for the 18th Annual Cefic-LRI Workshop, click here. On 17 November, the 18th Annual LRI Workshop will be held at The Square, in Brussels – you can find the programme here. For enquiries related to the workshop, please contact Dr. Bruno Hubesch, LRI Programme Manager, or the LRI Secretariat.

More rebel thinkers required!

Are you a real rebel thinker? Do you have a good idea for novel research in human health or environmental risk assessment? Then you can help your ideas come alive with the Cefic-LRI Innovative Science Award 2016. Your idea could be worth € 100 000! But be quick - the closing date for applications is 18 March 2016.

The European Chemical Industry Council (Cefic), in conjunction with Society of Environmental Toxicology and Chemistry (SETAC), Federation of Toxicologists and European Societies of Toxicology (EUROTOX), International Society of Exposure Scientists (ISES) and Chemical Week, is offering a €100,000 award to support promising new research in the field of novel approaches to the characterisation of molecular initiating events, or other key events, in pathways for human and environmental toxicity. But you must apply by 18 March 2016!

The award judges will be looking for innovative research ideas, focused either on human health or environmental safety, which can pioneer new approaches to identifying and characterising molecular initiating events (MIEs) and other key events or biomarkers that are relevant for important new Adverse Outcome Pathways (AOPs).

In 2012 the Organisation for Economic Cooperation and Development (OECD) launched a programme for the definition of AOPs as analytical constructs that describe series of linked events that are causally related and that lead to an adverse health outcome or environmental effect at the tissue, organism or population level. Such AOPs characteristically describe MIEs and other subsequent key events on the pathway to an adverse outcome.

The objective of the Cefic-LRI Innovative Science Award is to stimulate innovative research, "out-of-the-box" thinking and new approaches which will advance the assessment of hazardous substances.

The Cefic-LRI Innovative Science Award was established in 2004 to inspire highly innovative and industry relevant projects in biomedical toxicology and ecotoxicology led by promisingly early career scientists. The prize of € 100 000 has been awarded annually ever since - boosting the careers of twelve younger European scientists in the challenging research fields with which LRI is engaged.

Who can apply? 
The award is intended for a European-based scientist with less than ten years of research experience after their doctoral degree. Active involvement in interdisciplinary research, their current academic track record, and access to appropriate networks will be considered in the selection of the finalists.

Valid entries submitted by end-of-play on 18 March will be assessed by a panel of judges to select three finalists, who will be invited to present their ideas in Brussels on 6 June 2016, where the ultimate winner will be decided.

The LRI Innovative Science Award will be officially presented at the LRI Annual Workshop on 16 November 2016 and the 2016 Awardee will be expected to present the results of his or her research at the LRI Annual Workshop in November 2017.

For more details on the Cefic-LRI award and how to apply visit the awards webpage.

What is LRI?
The Long-range Research Initiative (LRI) programme is a major voluntary initiative of the European chemical industry to support the long-term sustainability of its sector and European society. Through the programme we hope to identify the hazards posed by chemicals and improve the methods available for assessing the associated risks.

The LRI sponsors high-quality research of a standard publishable in a reputable peer-reviewed journal, and seeks to provide sound scientific advice on which industry and regulatory bodies can draw-on to respond quickly and accurately to the public's concerns.

LRI AMBIT Workshop

Cefic’s Long-Range Research Initiative (LRI) is organising a training workshop on the AMBIT tool on 21 January at Cefic’s Brussels offices. AMBIT tool is a predictive toxicity model based on read-across and categorisation. The tool is a web-based application freely available to all and could prove very useful for companies for both R&D and regulatory purposes – in particular for REACH.

The AMBIT tool is described on the LRI website and in more detail on its own website and in this presentation from the LRI 2015 programme workshop.

The workshop is entitled ‘Linking LRI AMBIT Chemo informatics system with the IUCLID Substance database to support Read across of Substance endpoint data and Category formation.’
AMBIT is an essential component of the LRI toolbox of methods and instruments, while IUCLID (International Uniform Chemical Information Database) is a key tool for the chemical community to fulfil data submission obligations under REACH. The linking of the two systems was undertaken in LRI project EEM9.3.

The inclusion of high quality substance data will enhance the predictive power of the AMBIT in-silico tool. The new version of AMBIT also implements workflows for assessments and should minimise overall animal testing needs and resource costs.

Another important new feature is the automatic assignment of chemical structures from the AMBIT structure pool to all the constituents, impurities and additives defined in an IUCLID substance. A search for a defined structure yields relevant substances and endpoint data that could be filtered as required by the user.

In addition AMBIT has several output options including the generation of an assessment report as a Word document that itemises justification/ validation of the approach taken.

AMBIT is an open source application with many functions that can be further developed or customised. The EEM9.3 project ended this month (December 2015) and the new version of AMBIT will become a free, open, publicly available tool.

The AMBIT workshop on 21 January will allow users to gain “hands on” experience of the new system.

Free registration
There is no charge for attendance at the AMBIT workshop but places are restricted to a maximum of 50 participants – so reserve you seat now! You can view the programme of the workshop here.

To register, please send an email to Andreea Udrea withh cc to LRI Programme Manager Bruno Hubesch. Places will be allocated on a ‘first come first served basis’.

For more information on LRI activities, please contact Dr. Bruno Hubesch, LRI Programme Manager or the LRI Secretariat.

Rebel thinkers required!

Are you a rebel thinker? Do you have a good idea for novel research in human health or environmental risk assessment? Then you can help your ideas come alive with the Cefic-LRI Innovative Science Award 2015. But be quick - the closing date for applications is 17 March 2015.

The European Chemical Industry Council (Cefic), in conjunction with the Society of Environmental Toxicology and Chemistry (SETAC), the Federation of Toxicologists and European Societies of Toxicology (EUROTOX), the International Society of Exposure Scientists (ISES) and global chemicals news organisation IHS Chemical Week, is offering a €100,000 award to support promising new research in the field of novel use of surrogate data to assess apical endpoints in human health and/or environmental risk assessment. But you must apply by 17 March 2015!

Apical endpoints are empirically verifiable outcomes of exposure, such as developmental anomalies, breeding behaviours, impaired reproduction, physical changes and alterations in the size and histopathology of organs etc. These gross changes observed in-vivo can offer evidence of toxicity for a substance being studied.

Criteria
The award judges will be looking for new approaches and techniques that, in addressing the challenges of assessing chemical risks, will enhance our understanding of the causes of adverse effects. 

These could include, but are not limited to, one or more of the following:

• Techniques to combine different types of existing information on similar chemical(s);
• The use of predictive computational modelling such as Quantitative Structure Activity Relationships (QSARs);
• Novel non-animal toxicology testing, for example in-vitro and/ or high-throughput screening assays.

The objective of the Cefic-LRI Award is to stimulate innovative research, "out-of-the-box" thinking and new approaches which will advance the environmental assessment of hazardous substances.

The Cefic-LRI Innovative Science Award was established in 2004 to inspire highly innovative and industry relevant projects in biomedical toxicology and ecotoxicology led by promisingly early career scientists. The prize of € 100 000 has been awarded annually ever since; boosting the careers of eleven younger European scientists in the challenging fields with which LRI is engaged.

Who can apply? 
The award is intended for a European-based scientist with less than ten years of research experience after their doctoral degree. Active involvement in interdisciplinary research, their current academic track record, and access to appropriate networks will be considered in the selection of the finalists. 

Valid entries submitted by end-of-play on 17 March will be assessed by a panel of judges to select three finalists, who will be invited to present their ideas in Brussels on 1 June 2015, where the ultimate winner will be decided.

For more details on the Cefic-LRI award and how to apply, please visit the awards webpage.

What is LRI?
The Long-range Research Initiative (LRI) programme is a major voluntary initiative of the European chemical industry to support the long-term sustainability of its sector and European society. Through the programme we hope to identify the hazards posed by chemicals and improve the methods available for assessing the associated risks.

The LRI sponsors high-quality research of a standard publishable in a reputable peer-reviewed journal, and seeks to provide sound scientific advice on which industry and regulatory bodies can draw-on to respond quickly and accurately to the public's concerns.

One Million in Prizes! Ten years of LRI Innovative Science Awards

The recent LRI Annual Workshop in Brussels on 21 November was the occasion to celebrate ten years of the LRI Innovative Science award. The event saw the presentation of this prestigious award for younger scientists to its tenth recipient: Dr. Sabine Langie of VITO. Dr Langie received her prize of € 100 000 from Prof. Ellen Fritsche of the University of Dusseldorf: herself a previous winner and now a member of LRI’s External Scientific Advisory Panel (ESAP).

The Cefic-LRI award programme has been hugely successful over the past decade. The LRI Innovative Science Award was established in 2004 to inspire highly innovative and industry relevant projects in biomedical toxicology and ecotoxicology led by promisingly early career scientists.

The prize of € 100 000 has been awarded annually ever since - boosting the careers of ten younger European scientists in the challenging fields with which LRI is engaged.

This year’s award – making a total of one million euros distributed to research projects under this element of the Cefic-LRI programme so far – was presented by Prof Fritsche (below, left) to Dr Sabine Langie (below, right) of the Flemish Institute for Technological Research (VITO) at the LRI Annual Workshop.

Dr. Langie will use the award to broaden her current work on the analysis of DNA methylation patterns in the saliva of children participating in two significant birth cohort studies in Flanders. She is exploring the hypothesis that prenatal chemical exposures can alter foetal DNA methylation patterns and predispose the child to develop allergic diseases later in life.

The use of saliva is less burdensome for the children in study and easier to collect than, for example, blood samples. The ultimate aim of the study is to develop prevention strategies (including reduction of chemical exposure), particularly in children, and reduce the societal burden associated with allergic diseases.

Career boost
Reviewing the history of the award Prof. Fritsche, who won the award in 2006, described the prize as: “Nitromethane for an Early Career – the LRI award was a big accelerator for my career - a rocket!” This view was echoed by contributions from other awardees over the years.

Dr Roman Ashauer of York University won the award in 2007 and says: “The Cefic-LRI Award allowed me to pursue my own ideas. It was motivation, encouragement and the crucial bit of extra fuel in the tank to push the envelope.”

Similarly Prof Paul van den Brink of Wageningen University, the winner in 2005, commented: “The award gave me the first sense of academic freedom. It was a real push to my career and opened doors for further funding.”

The first ever winner of the award in 2004 Prof Roger Godschalk of Maastricht University is still feeing the effects of the award saying: “With the LRI-award, I was able to put my ideas into practice. It eventually evolved in to my own research line at our institute, which I can continue to build even 10 years after winning the CEFIC LRI-award.”

“Winning this award has been a pivotal factor in my research and professional career. It has allowed me to create my research group, managing my own research budget and having two PhD students working alongside me in the project,” said 2010 winner Dr Maria Saborit of Birmingham University.

Data mining
Delegates to the LRI workshop also got an update on the work of 2012 winner Dr Andreas Bender of the University of Cambridge who is looking to determine biologically relevant effects of compound exposure by chemical, biological and phenotypic data integration.

The in-silico prediction of in-vivo toxicology of a particular compound is a non trivial problem due to the lack of direct correlations between structural features and toxicity. However chemical, protein target and phenotypic data provide complementary bioactivity data and Dr Bender’s work is based on the hypothesis that more accurate toxicity predictions could be made by integrating these data. His core expertise is in data mining and the research has had success in predicting likely protein targets for compounds based on their structure in areas such as mode of action analysis, modelling of bioactivities, natural products and traditional medicines.

The performance of the model algorithm used is increasing all the time and Dr Bender is looking to the ultimate objective of automated prediction of targets given only their chemical structure. These techniques will be useful in future personalised medicine scenarios and he has recently received a € 1.5 million ERC Starter Grant to extend the work towards bioactive mixture modelling.

More information
Details of the next LRI Innovative Science Award will be released in early 2014. The focus of this eleventh competition will be in one of the environmental areas of research covered by LRI. For more details keep an eye on the Cefic-LRI website and to find out more about all previous winners click here.