EU FP7 project ‘KYROBIO' have produced an end of project webinar titled 'The Discovery, Development and Demonstration of Biocatalysis for use in the Industrial Synthesis of Chiral Chemicals'. The webinar gives a brief overview of the four year project whose main objective was to broaden the toolbox of single enantiomer chiral chemicals manufactured in Europe using biotechnological routes. Its specific focus was to enable the industrial application of the lyase class of enzymes which can selectively synthesise molecules with multiple chiral centres.
The KYROBIO project used an SME-focused approach to address industrially identified needs for chiral synthesis using biocatalysis with partners that have the potential to exploit the project results. The overarching challenge was that multiple chiral centres form a significant feature in several chosen industrially useful chemicals.
The control of reaction stereochemistry was targeted for added value in the KYROBIO technology. This leads to challenges in molecular biology, enzymology and process engineering to name but a few. All these areas are covered in the webinar that is embedded below. The project ran from 1 Dec 2011 to 30 November 2015.
About KYROBIO
The objective of KYROBIO project was to broaden the toolbox of single enantiomer chiral chemicals that are produced by industry in Europe using biotechnological routes. The main target is applications of lyase enzymes to selectively synthesize molecules with multiple chiral centres applying enzymatic carbon-carbon and carbon-nitrogen bond formation as the key technical platforms. Synthetic biological techniques were then applied to improve fermentation processes in order to generate better enzymes.
Chiral compounds are an important class of chemicals that have great potential to compete with chemocatalysts in their production processes with associated benefits from reduction in use of organic solvents, toxic metals and energy. However their application has been relatively limited so far. KYROBIO addressed the main challenges to moving forward to the next generation of added value industrial applications of white biotechnology for high value chemical synthesis.
Using a supradisciplinary approach ranging from enzyme development, chemistry, molecular biology, fermentation and innovative isolation techniques the bottlenecks to applying this new technology have been addressed.
KYROBIO has emphasised the dissemination of green sustainable chemistry to a broad audience of industry leaders, academics, policymakers and the public. Researchers have conducted a vigorous public outreach campaign including networking events, webinars, and public science education and training events.
The novel biocatalysts developed in the project are targeted for commercialisation within three years of the project completion. KYROBIO expects to put the EU at the forefront of efficient, sustainable and eco-friendly chemical production that benefits industry, consumers and the environment.
Dear colleagues and avid SusChem supporters, 2015 was an important year for SusChem: Early in the year we published the new SusChem Strategic Innovation and Research Agenda (SIRA) which is the result of intensive discussions with you and our other stakeholders. It focuses on the solutions that the chemical industry and its customers and partners in industrial value-chains can bring to tackle the societal challenges that Europe is facing. As such SusChem is an important contributor to the European innovation landscape.
When analysing the first round of Horizon 2020 calls that were issued for the 2014-2015 period, we found that more than 100 calls are connected to technologies described in the SusChem SIRA. We see a similar trend for the 2016-2017 calls. This emphasises in a very tangible way the central role that the chemical industry plays in carrying out Research and Innovation actions that have a significant impact for Europe.
More importantly, SusChem is committed to mobilise its stakeholders to participate in the European innovation effort. We do not only do this through our yearly brokerage event but also through special efforts e.g. dedicated to SMEs. During our stakeholder event in June 2015 we conducted a special brokerage session for SMEs. Here we created an opportunity for SMEs to link with other companies, creating room for companies to get to know the special innovations and business propositions of the SMEs.
Looking forward, SusChem is now engaged in establishing its roadmap for the five years to come, geared towards the implementation of the SIRA. After the kick-off during the Stakeholder event in June we are now working hard on identifying priorities that will be translated into specific initiatives and lighthouse projects. We are looking forward to discussing the outcome with you, soon.
The end of 2015 has also seen a successful conclusion to the COP 21 discussions in Paris. Beyond the global negotiation between states, we all know that the world will need technology solutions to support the transition towards an economy with substantially reduced CO2 emissions. Here, SusChem is uniquely positioned with sustainability as our fundamental theme and the SIRA clearly focused on the many contributions that the chemical and industrial biotechnology sectors can make.
On behalf of the SusChem Board and the SusChem secretariat, we wish you all very happy and relaxing holidays and a healthy, happy and “sustainable” New Year. 2016 will be another important year for SusChem and we expect to see the first results from the SusChem inspired projects that were launched in the first two years of Horizon 2020 and in which many of you are participating.
Best wishes
Dr Klaus H. Sommer
Chairman of the SusChem Board
Head Consumer and Product Management Bayer Technology Services
The event will focus on the results obtained during the E4Water project in terms of best practise for industrial water management and how this can provide challenges and opportunities for the chemical sector in particular the lessons learnt from the six case studies that form the core of the E4Water activities. Registration will open soon and the event will be free of charge.
A full programme for the conference will be available soon. To catch up with the latest news from the E4Water project download their latest newsletter.
What is E4Water?
With the chemical industry providing the highest potential to demonstrate increased eco-efficiency in industrial water management, the FP7 project ‘Economically and Ecologically Efficient Water Management in the European Chemical Industry’ (E4Water) addresses a range of crucial process needs to overcome bottlenecks and barriers to a fully integrated and energy efficient water management system.
The project’s main objective is to develop and test integrated approaches, methodologies and process technologies. There are six industrial case study sites at the core of E4Water that are expected to achieve a reduction of 20-40% in water use, 30-70% in waste water production, 15-40% in energy use and up to 60% in direct economic benefits. In addition to the chemical industry, the project is actively seeking opportunities for cross-fertilisation with other industrial sectors.
Cefic’s Long-Range Research Initiative (LRI) is organising a training workshop on the AMBIT tool on 21 January at Cefic’s Brussels offices. AMBIT tool is a predictive toxicity model based on read-across and categorisation. The tool is a web-based application freely available to all and could prove very useful for companies for both R&D and regulatory purposes – in particular for REACH.
The workshop is entitled ‘Linking LRI AMBIT Chemo informatics system with the IUCLID Substance database to support Read across of Substance endpoint data and Category formation.’
AMBIT is an essential component of the LRI toolbox of methods and instruments, while IUCLID (International Uniform Chemical Information Database) is a key tool for the chemical community to fulfil data submission obligations under REACH. The linking of the two systems was undertaken in LRI project EEM9.3.
The inclusion of high quality substance data will enhance the predictive power of the AMBIT in-silico tool. The new version of AMBIT also implements workflows for assessments and should minimise overall animal testing needs and resource costs.
Another important new feature is the automatic assignment of chemical structures from the AMBIT structure pool to all the constituents, impurities and additives defined in an IUCLID substance. A search for a defined structure yields relevant substances and endpoint data that could be filtered as required by the user.
In addition AMBIT has several output options including the generation of an assessment report as a Word document that itemises justification/ validation of the approach taken.
AMBIT is an open source application with many functions that can be further developed or customised. The EEM9.3 project ended this month (December 2015) and the new version of AMBIT will become a free, open, publicly available tool.
The AMBIT workshop on 21 January will allow users to gain “hands on” experience of the new system.
Free registration
There is no charge for attendance at the AMBIT workshop but places are restricted to a maximum of 50 participants – so reserve you seat now! You can view the programme of the workshop here.
The session covered changing attitudes and approaches by the chemical sector to biobased, the measures needed to accelerate uptake of renewable feedstocks, and views on the most significant recent developments in the biobased industry sector.
Transformative
The SusChem session highlighted the transformative nature of the bioeconomy and its strong impact on the chemical industry. This goes beyond mere adoption of new feedstock; the emergence of the bioeconomy can lead to entirely new value chains, products with new or enhanced functionality, new markets and new business models.
The panelists in the session shared optimistic perspectives on its theme of the ‘chemical industry catching up with biobased’ including several highly relevant success stories. But they also expressed an array of motivations for considering biobased feedstock ranging from an opportunistic approach (the new properties and improved competitiveness that certain biobased products could provide) to strong consumer demand for some segments of the industry and longer term sustainability objectives.
The rational choice of raw materials and their smart use is a key factor for better resource and energy efficiency - indeed the bioeconomy is one option for the chemical industry to reach its challenging sustainability objectives. Therefore the chemical industry needs to be prepared to foster industrial symbiosis combining different technologies in a truly sustainable approach. For example, the combination of chemical and biotechnological processes can provide the tools to maximize the full potential of biomass.
“A Biorefinery is a good example of Industrial Symbiosis as it requires multiple partners”
Considering upstream aspects of the biobased value chain, raw material availability and feedstock price are major drivers that influence directly the development of new biobased products. On the other hand, consumer needs must be taken into consideration since the conception phase of new products and markets, as well as transparency via product labelling, are important to increase the acceptance of biobased products in society.
Cultural barriers and skills
The discussion covered the need to overcome cultural barriers with new or unusual partners and the necessity for the chemical industry to deal more closely with upstream partners in the biobased value chains. Looking at the challenge for another perspective an interesting question was: “Is biobased prepared to be part of the chemical industry?”
Panelists also stressed the need to communicate more and better to society/ the general public about the benefits of biobased products and services.
An interesting discussion within the panel and with the audience touched upon the skills required to develop the bioeconomy. New skills, including ways to work across different disciplines, are strongly required for the development of biobased value chains. However “the borders between disciplines are blurred” and this is a challenge that needs to be addressed.
SusChem and the bioeconomy
Industrial Biotechnology is currently worth €23 billion representing just 6% of sales in the overall worldwide chemicals market. However, the sector is significantly out-performing the overall chemicals market at an impressive 20% annual growth rate and has the potential to become the dominant technology of tomorrow’s chemicals industry.
The SusChem Strategic Innovation and Research Agenda (SIRA) includes a dedicated chapter on ‘A Sustainable and Inclusive Bioeconomy’ and SusChem is an essential link between the chemical industry, industrial biotechnology and stakeholders in the bioeconomy.
The platform is actively involved in two large and relevant PPPs between the European Commission and industry launched in 2014:
The joint technology initiative ‘Biobased Industries’ (BBI) that brings together research and industry partners along the whole value chain of biobased products and focuses on innovation for products from biobased feedstock.
SusChem contributes to the alignment of both initiatives. The interface between BBI and
SPIRE is the provision and use of biobased platform chemicals. In addition, both PPPs may support projects using biotechnological conversion processes and specific improvements of biotechnology processes may be eligible for funding through either PPP. SusChem will enable the coherence of on-going and future funding initiatives and the deployment of flagship projects that demonstrate technological leadership and that Europe is a globally competitive location to invest in the bioeconomy.
EFIB 2015 Highlights
Further reporting on the activities at EFIB2015 and preliminary details on EFIB2016 to be held in Glasgow from 18 to 20 October 2016 can be accessed via the EFIB website.
A short video featuring highlights from the EFIB2015 conference and exhibition is embedded below.
On 10 December at the European Investment Bank's conference 'Financing the Circular Economy', EU Commissioner for Environment, Maritime Affairs and Fisheries, Karmenu Vella, presented some instruments to facilitate access to credit for businesses, in particular for small and medium enterprises (SMEs), to help them shift towards the circular economy model.
At the conference in Luxembourg the European Commission, the European Investment Bank and the Ministry of Economy of Luxembourg signed an amendment to the InnovFin Delegation Agreement that will enable higher-risk, yet innovative sustainable business models to access credit through InnovFin - an EU finance support programme under Horizon 2020.
At the conference Commissioner Vella highlighted that: "Today's event is all about making real changes on the ground. We want to give businesses more certainties when they innovate. New ideas also mean taking risks. The EU will help companies take the innovative risks needed to make real breakthroughs with more durable, repairable and more resource-efficient products".
InnovFin
Under Horizon 2020 the European Commission and the European Investment Bank Group (EIB and EIF) launched a new generation of financial instruments and advisory services in 2014 to help innovative firms access finance more easily. Until 2020, "InnovFin – EU Finance for Innovators" will offer a range of tailored products which will make available over EUR 24 billion of financing support for research and innovation (R&I) by small, medium-sized and large companies and the promoters of research infrastructures. This finance is expected to support up to EUR 48 billion of final R&I investments.
Backed by funds set aside under Horizon 2020 and by the EIB Group, InnovFin financial products support R&I activities, which by their nature are riskier and harder to assess than traditional investments, and therefore often face difficulties in accessing finance. All are demand-driven instruments, with no prior allocations between sectors, countries or regions. SusChem, Finance and SMEs
Coinciding with the #SusChem2015 stakeholder event earlier this year, SusChem published a new Guide to Innovation Funding for SMEs in Europe (left). The publication outlines five dedicated SME funding schemes (including InnovFinn) and describes how SusChem can help SMEs get involved with collaborative research and innovation projects.
The concept of 'lightweighting' refers to a means of construction with respect to materials and manufacturing that aims to reduce the mass and increase the quality of a product and all its component elements. The available data suggests that achieving a 10% decrease in weight within the broadly defined area of mobility (including cars, trucks, transport and machinery) would contribute to a reduction in emissions of some 100 million tonnes of CO2 in Germany alone - and about three billion tonnes worldwide.
For advanced manufacturing lightweight construction is a crucial factor. However, it is not just enough to integrate a small number of lightweight parts into the process of manufacturing. Lightweight design needs a holistic approach from the choice of appropriate materials and the manufacturing process itself to consideration of the efficient and low-cost recycling of the product after its use.
Questions
The ERRIN workshop aims to give an overview of state of play and recent developments in advanced manufacturing and to attempt to answer a range of questions including:
How do we prevent too much waste of lightweight components when it comes to mass production? Are there limits to lightweighting in construction?
How will changes in weight affect the driving behaviour of an extremely lightweight car?
How can we recycle to the maximum components of a lightweight product after use?
The workshop will take place on 16 December from 09:00 to 13:30 at the Saxony Liaison Office in Brussels at Avenue d’Auderghem 67, 1040 Brussels. The event is organised by ERRIN's Advanced Manufacturing and Nanotech working group.
The workshop will include presentations from Prof.Dr.LotharKroll of theTechnicalUniversityofChemnitz,LaszloBax of Bax andWillemsConsulting and Prof.DavidBailey of the AstonBusinessSchool in Birmingham.
The workshop will conclude with a panel discussion: 'LightweightinEurope:Wherearewe?Wheredowewanttogoto?Whathasto be done?' with representatives from industry, academia and the European Commission.
About ERRIN
Founded in 2001, ERRIN is a unique Brussels-based platform of more than 120 regional stakeholder organisations most of whom are represented by their Brussels offices. ERRIN promotes knowledge exchange between its members, focusing on joint actions and project partnerships to strengthen regional research and innovation capacities. Through these actions ERRIN seeks to contribute to the implementation of the Europe 2020 Strategy, the Innovation Union flagship initiative and Smart Specialisation strategies.
